Health

Wie lange verweilt COVID-19 in Ihrem Körper? Neuer Bericht gibt Hinweise.

Die meisten COVID-19-Patienten erholen sich von ihrer akuten Infektion innerhalb von zwei Wochen, aber Teile des Virus verschwinden nicht immer sofort aus dem Körper der Patienten. Jetzt ein neues Studie, eine der größten, die sich auf hospitalisierte COVID-19-Patienten konzentriert, zeigt dass einige Patienten diese Virusreste wochen- bis monatelang beherbergen, nachdem ihre primären COVID-19-Symptome abgeklungen sind.

Die Studie legt nahe, dass Patienten, wenn das genetische Material des Virus, RNA genannt, länger als 14 Tage im Körper verweilt, schlechtere Krankheitsverläufe erleiden, ein Delir erleben, länger im Krankenhaus bleiben und ein höheres Risiko haben, an COVID zu sterben. 19 verglichen mit denen, die das Virus schnell beseitigten. Die Persistenz des Virus kann auch bei Long COVID eine Rolle spielen, der schwächenden Reihe von Symptomen, die Monate andauern können. Schätzungen gehen davon aus, dass zwischen 7,7 und 23 Millionen Menschen allein in den Vereinigten Staaten sind nun schon lange von COVID betroffen.

Ohne Immunität gegen eine Impfung oder eine frühere Infektion wird SARS-CoV-2 – das Virus, das COVID-19 verursacht –repliziert und verbreitet durch den Körper und wird durch Nase, Mund und Darm ausgeschieden. Aber für die meisten Infizierten Die Viruskonzentration im Körper erreicht ihren Höhepunkt zwischen drei und sechs Tagen nach der ursprünglichen Infektion, und das Immunsystem beseitigt den Erreger innerhalb von 10 Tagen. Das Virenausscheidung nach dieser Zeit ist im Allgemeinen nicht ansteckend.

Selbst nach Berücksichtigung der Schwere der Erkrankung, unabhängig davon, ob die Patienten intubiert waren oder zugrunde liegende medizinische Komorbiditäten hatten, „gibt es hier etwas, das darauf hindeutet, dass Patienten, die anhaltend PCR-positiv sind, schlechtere Ergebnisse haben“, sagt er. Ayush Batraein Neurologe an der Northwestern University Feinberg School of Medicine, der die neue Studie leitete.

Die Studie von Batra zeigt, dass Patienten, die während einer akuten Infektion länger ausfielen, schwerwiegendere Folgen von COVID-19 riskieren, sagt er Timotheus Henrich, ein Virologe und Immunologe an der University of California, San Francisco, der nicht an der neuen Forschung beteiligt war. Die Studie untersucht jedoch nicht, ob dieses hartnäckige Virus direkt für lange COVID verantwortlich ist.

„Es gibt mehrere führende Hypothesen über die Ursache einer langen COVID, einschließlich der Viruspersistenz, und es kann sein, dass mehrere Wege im Spiel sind, vielleicht in unterschiedlichem Maße bei jeder Person“, sagt er. Linda Genein Arzt bei Stanford Health Care, der eine neu eröffnete Klinik für das postakute COVID-19-Syndrom zur Behandlung von Patienten mit langer COVID-19-Erkrankung mitleitet.

Ein persistierendes Virus verursacht schlechtere COVID-19-Ergebnisse

Batra und sein Team begannen mit der Untersuchung anhaltender Coronavirus-Infektionen, nachdem sie festgestellt hatten, dass einige Patienten, die ins Krankenhaus zurückkehrten, vier oder fünf Wochen nach der Diagnose der Erstinfektion immer noch positiv auf das Virus getestet wurden.

Für ihre neue Studie analysierte das Team 2.518 COVID-19-Patienten, die zwischen März und August 2020 im Gesundheitssystem Northwestern Medicine ins Krankenhaus eingeliefert wurden. Sie konzentrierten sich auf PCR-Tests gilt als Goldstandardda solche Tests genetisches Material des Virus nachweisen, hochempfindlich sind und weniger wahrscheinlich falsch negative Ergebnisse liefern.

Das Team stellte fest, dass 42 Prozent der Patienten zwei Wochen oder länger nach ihrer Erstdiagnose weiterhin PCR-positiv getestet wurden. Nach mehr als 90 Tagen wurden 12 Prozent der hartnäckigen Ausscheider immer noch positiv getestet; eine Person wurde 269 Tage nach der ursprünglichen Infektion positiv getestet.

Virale Persistenz wurde bereits in früheren kleineren Studien festgestellt. Forscher zeigten, dass auch Patienten ohne offensichtliche COVID-19-Symptome SARS-CoV-2 für a in sich trugen ein paar Monate und darüber hinaus. Bei einigen immungeschwächten Patienten das Virus dürfen ein Jahr lang nicht gelöscht werden. Vier Prozent der COVID-19-Patienten in a Studie zur chronischen COVID-19-Infektion in Stanford weiter scheiden sieben Monate später virale RNA im Kot aus Diagnose. Die Studie von Batra zeigt jedoch, dass eine größere Anzahl von Patienten länger braucht, um das Virus zu beseitigen, als bisher angenommen.

„Anhaltendes RNA-Shedding würde bedeuten, dass irgendwo im Körper noch ein Virusreservoir vorhanden ist“, sagt er Michael Van Elzakker, ein Neurowissenschaftler, der dem Massachusetts General Hospital, der Harvard Medical School und der Tufts University angehört. Solch Es wird angenommen, dass Stauseen das Fortbestehen des Virus ermöglichen über einen langen Zeitraum und könnte das Immunsystem dazu veranlassen, abweichend zu handeln, was möglicherweise eine lange COVID verursacht.

„Einige Patienten sind aus verschiedenen Gründen nicht in der Lage, dieses Reservoir zu beseitigen, oder ihr Immunsystem reagiert auf eine abnormale Weise, was zu diesen anhaltenden Symptomen führt, die als Long-COVID bezeichnet werden“, sagt Batra.

Dennoch glauben viele Wissenschaftler, dass es noch nicht genügend Beweise gibt, um die Persistenz viraler RNA mit langer COVID in Verbindung zu bringen.

Schlafende Viren

Die Liste menschlicher Gewebe, in denen sich SARS-CoV-2 lange nach der Erstinfektion versteckt, wächst. Studien haben das Virus oder genetisches Material daraus identifiziert Darm von Patienten vier Monate nach der Erstinfektion und innerhalb der Lunge eines verstorbenen Spenders mehr als hundert Tage nach der Genesung von COVID-19. Eine Studie, die noch nicht von Experten begutachtet wurde, entdeckte das Virus auch in der Appendix und Brustgewebe 175 bzw. 462 Tage nach Coronavirus-Infektionen. Und Forschungsergebnisse der US National Institutes of Health, die ebenfalls noch nicht von Experten begutachtet wurden erkannte SARS-CoV-2-RNA, die in niedrigen Konzentrationen persistiert über mehrere Gewebe für mehr als sieben Monate, selbst wenn es im Blut nicht nachweisbar war.

„Es ist nicht verwunderlich, Viren zu finden, denen man im Laufe des Lebens begegnet ist“, die in menschlichem Gewebe überleben, sagt er Kei Sato, Virologe an der Universität Tokio. Tatsächlich hat Satos Arbeit gezeigt, dass Menschen häufig Viren wie das Epstein-Barr-Virus, das Varizella-Zoster-Virus (das Windpocken verursacht) und viele Herpesviren ansammeln ruhende Formen. Diese persistierenden Viren sind typischerweise in geringen Konzentrationen vorhanden, sodass sie nur durch umfangreiche genetische Sequenzierung identifiziert werden können.

Dies zeigt, wie kompliziert es ist, den Zusammenhang zwischen persistierendem SARS-CoV-2 und langem COVID zu beweisen oder zu widerlegen. Gürtelrose zum Beispiel tritt Jahrzehnte nach einer Windpockeninfektion aufwenn das latente Virus bei Immunstress reaktiviert wird.

Ebenso könnte anhaltendes SARS-CoV-2 langfristige Gesundheitsprobleme verursachen. Henrich glaubt, wenn das Virus in tiefes Gewebe gesät wird, kann es möglicherweise dazu führen, dass sich das Immunsystem in a fehlregulierter Entzündungszustand. Ein solcher Zustand ist „wahrscheinlich ein Beweis dafür, dass das Virus in der Lage ist, zu überleben und vielleicht in eine Art unruhigen Waffenstillstand mit dem Körper zu geraten“, sagt VanElzakker.

Um jedoch einen anhaltenden Virus mit einer langen COVID in Verbindung zu bringen, sind umfangreiche Studien erforderlich. „Wir wissen immer noch nicht genug, um aussagekräftige Schlussfolgerungen über einen der derzeit vorgeschlagenen Mechanismen zu ziehen, aber es wird aktiv geforscht, um diese Fragen zu beantworten“, sagt Geng.

Die Beseitigung hartnäckiger Viren könnte lange COVID heilen

Beide Geng und Henrichs Gruppes haben vorläufige Fallstudien berichtet, die eine zeigen Verbesserung der langen COVID-Symptome, nachdem Patienten mit dem oralen antiviralen COVID-19-Medikament Paxlovid von Pfizer behandelt wurden. Paxlovid stoppt die Replikation des Virus, weshalb einige Experten glauben, dass es alle verbleibenden Viren beseitigen kann. Beide Autoren raten jedoch zur Vorsicht, bevor sie davon ausgehen, dass Paxlovid sicher, wirksam oder ausreichend und damit ein zuverlässiges Heilmittel für lange COVID sein wird.

„Es gibt einige interessante Hypothesen darüber, wie Paxlovid bei der Behandlung von langem COVID nützlich sein könnte, aber wir bräuchten weitere Untersuchungen und klinische Studien, bevor wir zu Schlussfolgerungen kommen können“, sagt Geng.

Die US Food and Drug Administration hat warnte vor Off-Label-Anwendungen von Paxlovid, das nicht für eine lange COVID-Behandlung zugelassen ist. Die Agentur hat Paxlovid eine gegeben Notfallgenehmigung zur Behandlung von leichtem bis mittelschwerem COVID-19 bei Personen, bei denen das Risiko besteht, dass sie eine schwere Erkrankung entwickeln, zweimal täglich für fünf Tage kurz nach einem positiven Test.

„Es wäre wichtig, die optimale Behandlungsdauer zu berücksichtigen [of Paxlovid] um langfristige und nachhaltige Ergebnisse zu gewährleisten “, sagt Geng.

Präsident Joe Biden hat den Minister für Gesundheit und menschliche Dienste geleitet um einen nationalen Aktionsplan zu langem COVID zu erstellenund das NIH hat eine mehrjährige Studie namens gestartet GENESEN um langfristige gesundheitliche Auswirkungen im Zusammenhang mit COVID-19 zu verstehen, zu verhindern und zu behandeln.

In der Zwischenzeit schützen Impfstoffe nicht nur weiterhin vor schweren Erkrankungen, sondern es gibt auch Hinweise darauf, dass sie viele lange COVID-Symptome verhindern können. Eins neu Studie verglich 1,5 Millionen ungeimpfte COVID-19-Patienten mit 25.225 geimpften Patienten mit Durchbruchinfektionen, und es stellte sich heraus, dass Impfstoffe das Risiko, 28 Tage nach einer Infektion lange COVID-Symptome zu entwickeln, signifikant reduzierten. Die Schutzwirkung der Impfung wurde 90 Tage nach der Infektion sogar noch größer.

„Obwohl die Mehrheit der Menschen COVID nicht lange entwickelt, ist es sicherlich ein Risiko, und COVID hört nicht nach den ersten 10 Tagen der Infektion auf“, sagt Henrich. „Für diejenigen, die COVID nicht ernst nehmen, kann es sein Leben verändern.”

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Now a new study, one of the largest focusing on hospitalized COVID-19 patients, shows that some patients harbor these viral remnants for weeks to months after their primary COVID-19 symptoms resolve.”},”type”:”p”},{“id”:”html1″,”cntnt”:{“mrkup”:”The study suggests that when the genetic material of the virus, called RNA, lingers in the body longer than 14 days, patients may face worse disease outcomes, experience delirium, stay longer in the hospital, and have a higher risk of dying from COVID-19 compared with those who cleared the virus rapidly. The persistence of the virus may also play a role in long COVID, the debilitating suite of symptoms that can last for months. Estimates suggest between 7.7 and 23 million people in the United States alone are now affected by long COVID.”},”type”:”p”},{“id”:”html2″,”cntnt”:{“mrkup”:”Without immunity from vaccination or a previous infection, SARS-CoV-2—the virus that causes COVID-19—replicates and spreads throughout the body and is shed through the nose, mouth, and gut. But for most infected people, virus levels in the body peak between three and six days after the original infection, and the immune system clears the pathogen within 10 days. The virus shed after this period is generally not infectious.”},”type”:”p”},{“id”:”html3″,”cntnt”:{“mrkup”:”Even after accounting for disease severity, whether the patients were intubated, or had underlying medical comorbidities, “there is something here that signals that patients who are persistently PCR positive have worse outcomes,” says Ayush Batra, a neurologist at Northwestern University Feinberg School of Medicine, who led the new study.”},”type”:”p”},{“id”:”html4″,”cntnt”:{“mrkup”:”Batra’s study shows that patients who had prolonged shedding during an acute infection risk more severe outcomes from COVID-19, says Timothy Henrich, a virologist and immunologist at the University of California, San Francisco who was not involved in the new research. But the study doesn’t investigate whether this persistent virus is directly responsible for long COVID.”},”type”:”p”},{“id”:”html5″,”cntnt”:{“mrkup”:”“There are multiple leading hypotheses out there about the cause of long COVID, including viral persistence, and it may be that there are multiple pathways at play, perhaps to some varying degree in any one person,” says Linda Geng, a doctor at Stanford Health Care who co-directs a newly opened Post-Acute COVID-19 Syndrome Clinic for treating long COVID sufferers.”},”type”:”p”},{“id”:”html6″,”cntnt”:{“mrkup”:”Persisting virus causes worse COVID-19 outcomes”},”type”:”h2″},{“id”:”html7″,”cntnt”:{“mrkup”:”Batra and his team began studying persistent coronavirus infections after observing that some patients who were returning to the hospital were still testing positive for the virus four or five weeks after they were diagnosed with the initial infection.”},”type”:”p”},{“id”:”html8″,”cntnt”:{“mrkup”:”For their new study, the team analyzed 2,518 COVID-19 patients hospitalized in the Northwestern Medicine Healthcare system between March and August 2020. They focused on PCR tests, which are considered the gold standard, because such tests detect genetic material from the virus and so are highly sensitive and less likely to return false negatives.”},”type”:”p”},{“id”:”html9″,”cntnt”:{“mrkup”:”The team found that 42 percent of patients continued to test PCR positive two weeks or longer after their initial diagnosis. After more than 90 days, 12 percent of the persistent shedders were still testing positive; one person tested positive 269 days after the original infection.”},”type”:”p”},{“id”:”html10″,”cntnt”:{“mrkup”:”Viral persistence has been noted before in previous smaller studies. Researchers showed that even patients without obvious COVID-19 symptoms harbored SARS-CoV-2 for a couple of months and beyond. In some immunocompromised patients, the virus may not be cleared for a year. Four percent of COVID-19 patients in a trial on chronic COVID-19 infection at Stanford continued to shed viral RNA in feces seven months after diagnosis. However, Batra’s study illustrates that a larger number of patients take longer to clear the virus than previously realized.”},”type”:”p”},{“id”:”html11″,”cntnt”:{“mrkup”:”“Persistent RNA shedding would mean that there still is a reservoir of virus somewhere in the body,” says Michael VanElzakker, a neuroscientist affiliated with Massachusetts General Hospital, Harvard Medical School and Tufts University. Such reservoirs are thought to allow the virus to persist over a long period of time and could trigger the immune system to act aberrantly, perhaps causing long COVID.”},”type”:”p”},{“id”:”html12″,”cntnt”:{“mrkup”:”“Some patients, for variety of reasons, are not able to clear this reservoir, or their immune system reacts in some abnormal way that results in these persistent symptoms that have come to be termed as long COVID,” says Batra.”},”type”:”p”},{“id”:”html13″,”cntnt”:{“mrkup”:”Still, many scientists don’t think there is sufficient evidence yet to link the persistence of viral RNA to long COVID.”},”type”:”p”},{“id”:”html14″,”cntnt”:{“mrkup”:”Sleeping viruses”},”type”:”h2″},{“id”:”html15″,”cntnt”:{“mrkup”:”The list of human tissues where SARS-CoV-2 hides long after the initial infection is growing. Studies have identified the virus, or genetic material from it, in the intestines of patients four months after initial infection, and inside the lung of a deceased donor more than a hundred days after recovery from COVID-19. One study that’s not yet peer reviewed also detected the virus in the appendix and breast tissues 175 and 462 days, respectively, after coronavirus infections. And research from the U.S. National Institutes of Health that’s also not yet peer reviewed detected SARS-CoV-2 RNA persisting at low levels across multiple tissues for more than seven months, even when it was undetectable in blood.”},”type”:”p”},{“id”:”html16″,”cntnt”:{“mrkup”:”“It is not surprising to find viruses encountered during the lifetime” surviving in human tissues, says Kei Sato, a virologist at the University of Tokyo. Indeed, Sato’s work has shown that humans frequently accumulate viruses such as Epstein-Barr virus, varicella zoster virus (which causes chicken pox), and many herpes viruses in dormant forms. These persisting viruses are typically present at low levels, so only extensive genetic sequencing can identify them.”},”type”:”p”},{“id”:”html17″,”cntnt”:{“mrkup”:”This highlights how complicated it is to prove or disprove the association between persisting SARS-CoV-2 and long COVID. Shingles, for example, occurs decades after a chickenpox infection, when the latent virus gets reactivated during immune stress.”},”type”:”p”},{“id”:”html18″,”cntnt”:{“mrkup”:”Likewise, lingering SARS-CoV-2 could cause long-term health problems. Henrich thinks when the virus is seeded in deep tissues, it potentially causes the immune system to shift into a dysregulated inflammatory state. Such a state is “probably evidence that the virus is capable of persisting, and maybe getting down into sort of an uneasy truce with the body,” says VanElzakker.”},”type”:”p”},{“id”:”html19″,”cntnt”:{“mrkup”:”Still, associating any lingering virus with long COVID will require extensive studies. “We still don’t know enough to make strong conclusions about any of the current proposed mechanisms, but research is actively underway to answer those questions,” says Geng.”},”type”:”p”},{“id”:”html20″,”cntnt”:{“mrkup”:”Clearing up persistent virus might cure long COVID “},”type”:”h2″},{“id”:”html21″,”cntnt”:{“mrkup”:”Both Geng and Henrich’s groups have reported preliminary case studies that show an improvement in long COVID symptoms after patients were treated with Pfizer’s COVID-19 oral antiviral Paxlovid. Paxlovid stops the virus from replicating, which is why some experts think it can clear any lingering virus. But both authors urge caution before assuming that Paxlovid will be safe, effective, or sufficient and thereby a reliable cure for long COVID.”},”type”:”p”},{“id”:”html22″,”cntnt”:{“mrkup”:”“There are some interesting hypotheses about how Paxlovid may be useful in the treatment of long COVID, but we’d need further investigation and clinical trials before coming to any conclusions,” says Geng.”},”type”:”p”},{“id”:”html23″,”cntnt”:{“mrkup”:”The U.S. Food and Drug Administration has warned against off-label uses of Paxlovid, which is not approved for long COVID treatment. The agency has given Paxlovid an emergency use authorization to treat mild to moderate COVID-19 in those who are at risk of developing severe disease, twice daily for five days soon after a positive test.”},”type”:”p”},{“id”:”html24″,”cntnt”:{“mrkup”:”“It would be important to consider the optimal duration of treatment [of Paxlovid] to ensure long-term and sustained results,” says Geng.”},”type”:”p”},{“id”:”html25″,”cntnt”:{“mrkup”:”President Joe Biden has directed the secretary of Health and Human Services to create a national action plan on long COVID, and the NIH has launched a multi-year study called RECOVER to understand, prevent, and treat long-term health effects related to COVID-19.”},”type”:”p”},{“id”:”html26″,”cntnt”:{“mrkup”:”In the meantime, vaccines not only continue to protect against severe disease, but evidence is also emerging that they can prevent many long COVID symptoms. One new study compared 1.5 million unvaccinated COVID-19 patients to 25,225 vaccinated patients with breakthrough infections, and it found that vaccines significantly reduced the risk of developing long COVID symptoms 28 days after an infection. The protective effect of vaccination got even larger at 90 days post-infection.”},”type”:”p”},{“id”:”html27″,”cntnt”:{“mrkup”:””Although a majority of people do not develop long COVID, it’s certainly a risk, and COVID doesn’t stop after the first 10 days of becoming infected,” says Henrich. “For those who don’t take COVID seriously, it can be life changing.””},”type”:”p”}],”cid”:”drn:src:natgeo:unison::prod:c296fcbe-3b29-43a1-a97c-81bf096a1cf7″,”cntrbGrp”:[{“contributors”:[{“displayName”:”Sanjay Mishra”}],”title”:”By”,”rl”:”Writer”}],”mode”:”richtext”,”dscrptn”:”A comprehensive study found that viral remnants can survive for months after infection in certain people, perhaps causing some symptoms of long COVID.”,”enableAds”:true,”endbug”:true,”isMetered”:true,”isUserAuthed”:false,”ldMda”:{“cmsType”:”image”,”hasCopyright”:true,”id”:”9fea1d04-f5c2-4ce2-aa10-9cc94520497b”,”lines”:3,”positionMetaBottom”:true,”showMore”:true,”caption”:”A patient undergoes a chest CT scan at the Gemelli Polyclinic in Rome to check her lung status after COVID-19. “,”credit”:”Photograph by Marco Carmignan”,”image”:{“crps”:[{“nm”:”raw”,”aspRto”:1.2503052503052503,”url”:”https://i.natgeofe.com/n/855abc17-f064-44c9-b46f-d0ebb60688f9/LongCovid_MarcoCarmignan_14.jpg”},{“nm”:”16×9″,”aspRto”:1.7777777777777777,”url”:”https://i.natgeofe.com/n/855abc17-f064-44c9-b46f-d0ebb60688f9/LongCovid_MarcoCarmignan_14_16x9.jpg”},{“nm”:”3×2″,”aspRto”:1.5,”url”:”https://i.natgeofe.com/n/855abc17-f064-44c9-b46f-d0ebb60688f9/LongCovid_MarcoCarmignan_14_3x2.jpg”},{“nm”:”square”,”aspRto”:1,”url”:”https://i.natgeofe.com/n/855abc17-f064-44c9-b46f-d0ebb60688f9/LongCovid_MarcoCarmignan_14_square.jpg”},{“nm”:”2×3″,”aspRto”:0.6666666666666666,”url”:”https://i.natgeofe.com/n/855abc17-f064-44c9-b46f-d0ebb60688f9/LongCovid_MarcoCarmignan_14_2x3.jpg”},{“nm”:”3×4″,”aspRto”:0.75,”url”:”https://i.natgeofe.com/n/855abc17-f064-44c9-b46f-d0ebb60688f9/LongCovid_MarcoCarmignan_14_3x4.jpg”},{“nm”:”4×3″,”aspRto”:1.3333333333333333,”url”:”https://i.natgeofe.com/n/855abc17-f064-44c9-b46f-d0ebb60688f9/LongCovid_MarcoCarmignan_14_4x3.jpg”},{“nm”:”2×1″,”aspRto”:2,”url”:”https://i.natgeofe.com/n/855abc17-f064-44c9-b46f-d0ebb60688f9/LongCovid_MarcoCarmignan_14_2x1.jpg”}],”rt”:”https://i.natgeofe.com/n/855abc17-f064-44c9-b46f-d0ebb60688f9/LongCovid_MarcoCarmignan_14″,”src”:”https://i.natgeofe.com/n/855abc17-f064-44c9-b46f-d0ebb60688f9/LongCovid_MarcoCarmignan_14.jpg”,”altText”:”Picture of a patient’s arms sticking out from a CT scanner.”,”crdt”:”Photograph by Marco Carmignan”,”dsc”:”Stefania, 68, undergoes a chest CT scan at the Post Covid Day Hospital of the Gemelli Polyclinic to check her lung status after Covid-19 disease. Rome, 2020.”,”ext”:”jpg”,”ttl”:”Long_COVID_CT”},”imageAlt”:”Picture of a patient’s arms sticking out from a CT scanner.”,”imageSrc”:”https://i.natgeofe.com/n/855abc17-f064-44c9-b46f-d0ebb60688f9/LongCovid_MarcoCarmignan_14_16x9.jpg?w=636&h=358″,”hideEndBug”:true,”type”:”imageLead”,”hideLine”:true},”mdDt”:”2022-05-20T13:53:27.999Z”,”readTime”:”8 min read”,”schma”:{“athrs”:[{“name”:”Sanjay Mishra”}],”cnnicl”:”https://www.nationalgeographic.com/science/article/persisting-coronavirus-could-drag-out-covid-19-symptoms”,”kywrds”:”COVID-19, long COVID, virus”,”lg”:”https://assets-cdn.nationalgeographic.com/natgeo/static/default.NG.logo.dark.jpg”,”pblshr”:”National Geographic”,”abt”:”Coronavirus”,”sclDsc”:”A comprehensive study found that viral remnants can survive for months after infection in certain people, perhaps causing some symptoms of long COVID.”,”sclImg”:”https://i.natgeofe.com/n/855abc17-f064-44c9-b46f-d0ebb60688f9/LongCovid_MarcoCarmignan_14_16x9.jpg?w=1200″,”sclTtl”:”How long does COVID-19 linger in your body? New report offers clues.”},”sctn”:”Science”,”sctnLbls”:[{“name”:”Science”,”type”:”sources”,”uri”:”https://www.nationalgeographic.com/science”},{“name”:”Coronavirus Coverage”,”type”:”series”,”uri”:”https://www.nationalgeographic.com/science/topic/coronavirus-coverage”}],”shrURLs”:{“fbIcon”:”facebook”,”fb”:”https://www.facebook.com/sharer.php?u=https%3A%2F%2Fwww.nationalgeographic.com%2Fscience%2Farticle%2Fpersisting-coronavirus-could-drag-out-covid-19-symptoms”,”fbAriaLabel”:”article.facebookShare.ariaLabel”,”fbLabel”:”article.facebookShare.label”,”fbButtonTracking”:{“event_name”:”share”,”share_content_type”:”article”,”content_title”:”how long does covid-19 linger in your body? new report offers clues.”,”share_method”:”facebook”},”emailIcon”:”email__filled”,”email”:”mailto:?subject=How%20long%20does%20COVID-19%20linger%20in%20your%20body%3F%20New%20report%20offers%20clues.&body=A%20comprehensive%20study%20found%20that%20viral%20remnants%20can%20survive%20for%20months%20after%20infection%20in%20certain%20people%2C%20perhaps%20causing%20some%20symptoms%20of%20long%20COVID.%0A%0Ahttps%3A%2F%2Fwww.nationalgeographic.com%2Fscience%2Farticle%2Fpersisting-coronavirus-could-drag-out-covid-19-symptoms”,”emailLabel”:”Email”,”emailButtonTracking”:{“event_name”:”share”,”share_content_type”:”article”,”content_title”:”how long does covid-19 linger in your body? new report offers clues.”,”share_method”:”email”},”twitter”:”https://twitter.com/intent/tweet?url=https%3A%2F%2Fwww.nationalgeographic.com%2Fscience%2Farticle%2Fpersisting-coronavirus-could-drag-out-covid-19-symptoms&text=How%20long%20does%20COVID-19%20linger%20in%20your%20body%3F%20New%20report%20offers%20clues.&via=NatGeo”,”twitterLabel”:”Tweet”,”twitterButtonTracking”:{“event_name”:”share”,”share_content_type”:”article”,”content_title”:”how long does covid-19 linger in your body? new report offers clues.”,”share_method”:”twitter”}},”title”:”How long does COVID-19 linger in your body? New report offers clues.”,”wrdcnt”:1615,”amplnk”:”https://api.nationalgeographic.com/distribution/public/amp/science/article/persisting-coronavirus-could-drag-out-covid-19-symptoms”,”pbDt”:”2022-05-20T12:00:00.000Z”,”dt”:”2022-05-20T12:00:00.000Z”}]}],”cmsType”:”ArticleBodyFrame”},{“id”:”email-sticky-footer-frame1″,”mods”:[{“id”:”1695a8e9-54f6-4370-b124-31d9aaf89dac”,”cmsType”:”StackModule”,”align”:”left”,”edgs”:[{“id”:”6d05472e-f86d-4e24-980e-2e0d6d342f67″,”cmsType”:”EmailStickyFooterTile”,”title”:”Enter your email to continue reading”,”errorMessage”:”Please enter a valid e-mail address.”,”mrktngMeta”:{“cpgnCd”:”20220405_global_email wall_science”},”subtitle”:”Breaking discoveries and timely explainers delivered to your inbox—unsubscribe any time. Plus, unlock 3 free articles per month.”,”success”:{“description”:”

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Can implants and electrical signaling replicate the experience of touch? Research teams are exploring the possibilities—with startling results.”,”img”:{“crps”:[{“nm”:”raw”,”aspRto”:1.3617021276595744,”url”:”https://i.natgeofe.com/n/1ca4339d-ba44-4474-a82b-cff5304b781d/Science-of-Touch-MM9499-shadows-hands-1.jpg”},{“nm”:”16×9″,”aspRto”:1.7777777777777777,”url”:”https://i.natgeofe.com/n/1ca4339d-ba44-4474-a82b-cff5304b781d/Science-of-Touch-MM9499-shadows-hands-1_16x9.jpg”},{“nm”:”3×2″,”aspRto”:1.5,”url”:”https://i.natgeofe.com/n/1ca4339d-ba44-4474-a82b-cff5304b781d/Science-of-Touch-MM9499-shadows-hands-1_3x2.jpg”},{“nm”:”square”,”aspRto”:1,”url”:”https://i.natgeofe.com/n/1ca4339d-ba44-4474-a82b-cff5304b781d/Science-of-Touch-MM9499-shadows-hands-1_square.jpg”},{“nm”:”2×3″,”aspRto”:0.6666666666666666,”url”:”https://i.natgeofe.com/n/1ca4339d-ba44-4474-a82b-cff5304b781d/Science-of-Touch-MM9499-shadows-hands-1_2x3.jpg”},{“nm”:”3×4″,”aspRto”:0.75,”url”:”https://i.natgeofe.com/n/1ca4339d-ba44-4474-a82b-cff5304b781d/Science-of-Touch-MM9499-shadows-hands-1_3x4.jpg”},{“nm”:”4×3″,”aspRto”:1.3333333333333333,”url”:”https://i.natgeofe.com/n/1ca4339d-ba44-4474-a82b-cff5304b781d/Science-of-Touch-MM9499-shadows-hands-1_4x3.jpg”},{“nm”:”2×1″,”aspRto”:2,”url”:”https://i.natgeofe.com/n/1ca4339d-ba44-4474-a82b-cff5304b781d/Science-of-Touch-MM9499-shadows-hands-1_2x1.jpg”}],”rt”:”https://i.natgeofe.com/n/1ca4339d-ba44-4474-a82b-cff5304b781d/Science-of-Touch-MM9499-shadows-hands-1″,”src”:”https://i.natgeofe.com/n/1ca4339d-ba44-4474-a82b-cff5304b781d/Science-of-Touch-MM9499-shadows-hands-1.jpg”,”altText”:”Picture of shadows of three human hands on white material.”,”crdt”:”Photograph by Lynn Johnson”,”dsc”:”This translucent fabric acts as the skin of an experimental camera-computer combo that “feels” the touch of hands in a novel way—by converting their shadows into information. The Cornell University scientists who developed the mechanism, called Shadow Sense, are trying it out inside a soft, touchreactive robot.”,”ext”:”jpg”,”ratio”:”3×2″},”isFeatured”:true,”sections”:[{“name”:”Magazine”,”id”:”9af83c1e-1fdc-3710-b252-c42eedb1b7c1″,”type”:”sources”,”uri”:”https://www.nationalgeographic.com/magazine”}],”headline”:”The audacious science pushing the boundaries of human touch”,”link”:”https://www.nationalgeographic.com/magazine/article/the-audacious-science-pushing-the-boundaries-of-human-touch-feature”},{“description”:”The marine mammals use several cues, including unique whistles, to form a complex awareness of others in their minds.”,”img”:{“crps”:[{“nm”:”raw”,”aspRto”:1.7808695652173914,”url”:”https://i.natgeofe.com/n/935127ed-8987-44ae-8194-ff94643a794d/DQ_Camera-1.jpg”},{“nm”:”16×9″,”aspRto”:1.7777777777777777,”url”:”https://i.natgeofe.com/n/935127ed-8987-44ae-8194-ff94643a794d/DQ_Camera-1_16x9.jpg”},{“nm”:”3×2″,”aspRto”:1.5,”url”:”https://i.natgeofe.com/n/935127ed-8987-44ae-8194-ff94643a794d/DQ_Camera-1_3x2.jpg”},{“nm”:”square”,”aspRto”:1,”url”:”https://i.natgeofe.com/n/935127ed-8987-44ae-8194-ff94643a794d/DQ_Camera-1_square.jpg”},{“nm”:”2×3″,”aspRto”:0.6666666666666666,”url”:”https://i.natgeofe.com/n/935127ed-8987-44ae-8194-ff94643a794d/DQ_Camera-1_2x3.jpg”},{“nm”:”3×4″,”aspRto”:0.75,”url”:”https://i.natgeofe.com/n/935127ed-8987-44ae-8194-ff94643a794d/DQ_Camera-1_3x4.jpg”},{“nm”:”4×3″,”aspRto”:1.3333333333333333,”url”:”https://i.natgeofe.com/n/935127ed-8987-44ae-8194-ff94643a794d/DQ_Camera-1_4x3.jpg”},{“nm”:”2×1″,”aspRto”:2,”url”:”https://i.natgeofe.com/n/935127ed-8987-44ae-8194-ff94643a794d/DQ_Camera-1_2x1.jpg”}],”rt”:”https://i.natgeofe.com/n/935127ed-8987-44ae-8194-ff94643a794d/DQ_Camera-1″,”src”:”https://i.natgeofe.com/n/935127ed-8987-44ae-8194-ff94643a794d/DQ_Camera-1.jpg”,”altText”:”Picture of a dolphin underwater.”,”crdt”:”Photograph by Christian Adair/Dolphin Quest”,”dsc”:”A young dolphin calf explores the natural ocean-fed lagoon, teeming with marine life, at Dolphin Quest Bermuda. This lagoon mirrors the shallow bays and estuaries where this coastal ecotype of dolphin is found in the wild and allows for enriching physical stimulation and exploration without the threat of marine debris or predators.”,”ext”:”jpg”,”ttl”:”Dolphin_Quest”},”sections”:[{“name”:”Animals”,”id”:”fa010584-7bbf-3e92-90f9-586bb27fce94″,”type”:”sources”,”uri”:”https://www.nationalgeographic.com/animals”},{“name”:”Weird & Wild”,”id”:”d158de56-f10a-3f8c-90cd-7264bfca652a”,”type”:”series”,”uri”:”https://www.nationalgeographic.com/animals/topic/weird-wild”}],”headline”:”Dolphins can identify their friends by taste, study shows”,”link”:”https://www.nationalgeographic.com/animals/article/dolphins-use-their-sense-of-taste-to-identify-friends”},{“description”:”Discovered thousands of miles south of the only other known Denisovan fossils, the molar provides fresh evidence of the enigmatic humans’ spread across ancient Asia.”,”img”:{“crps”:[{“nm”:”raw”,”aspRto”:1.7777777777777777,”url”:”https://i.natgeofe.com/n/f7073d89-65a4-40ae-af6e-5dbabe9a7152/Demeter_panorama.jpg”},{“nm”:”16×9″,”aspRto”:1.7777777777777777,”url”:”https://i.natgeofe.com/n/f7073d89-65a4-40ae-af6e-5dbabe9a7152/Demeter_panorama_16x9.jpg”},{“nm”:”3×2″,”aspRto”:1.5,”url”:”https://i.natgeofe.com/n/f7073d89-65a4-40ae-af6e-5dbabe9a7152/Demeter_panorama_3x2.jpg”},{“nm”:”square”,”aspRto”:1,”url”:”https://i.natgeofe.com/n/f7073d89-65a4-40ae-af6e-5dbabe9a7152/Demeter_panorama_square.jpg”},{“nm”:”2×3″,”aspRto”:0.6666666666666666,”url”:”https://i.natgeofe.com/n/f7073d89-65a4-40ae-af6e-5dbabe9a7152/Demeter_panorama_2x3.jpg”},{“nm”:”3×4″,”aspRto”:0.75,”url”:”https://i.natgeofe.com/n/f7073d89-65a4-40ae-af6e-5dbabe9a7152/Demeter_panorama_3x4.jpg”},{“nm”:”4×3″,”aspRto”:1.3333333333333333,”url”:”https://i.natgeofe.com/n/f7073d89-65a4-40ae-af6e-5dbabe9a7152/Demeter_panorama_4x3.jpg”},{“nm”:”2×1″,”aspRto”:2,”url”:”https://i.natgeofe.com/n/f7073d89-65a4-40ae-af6e-5dbabe9a7152/Demeter_panorama_2x1.jpg”}],”rt”:”https://i.natgeofe.com/n/f7073d89-65a4-40ae-af6e-5dbabe9a7152/Demeter_panorama”,”src”:”https://i.natgeofe.com/n/f7073d89-65a4-40ae-af6e-5dbabe9a7152/Demeter_panorama.jpg”,”altText”:”Picture of”,”crdt”:”Photograph by Fabrice Demeter”,”dsc”:”Aerial view of the site and the entrance of Tam Ngu Hao 2 cave.”,”ext”:”jpg”,”ttl”:”Cobra_cave_site”},”sections”:[{“name”:”Science”,”id”:”2af51eeb-09a8-3bcf-8467-6b2a08edb76c”,”type”:”sources”,”uri”:”https://www.nationalgeographic.com/science”}],”headline”:”Tooth from mysterious human relative found in Laos”,”link”:”https://www.nationalgeographic.com/science/article/denisovan-tooth-found-in-laos-adds-new-wrinkles-to-their-story”},{“description”:”Three wildfires skirted the author’s Boulder home. 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Then two more converged on her ancestral house in New Mexico. In the drying West, people must now keep their “head on a swivel.””,”title”:”Their house has stood 130 years. A new fire era may change that.”,”tags”:[{“name”:”Environment”,”id”:”623ce370-3e67-3fb2-b9a5-070ceb9b2de5″,”type”:”sources”,”uri”:”https://www.nationalgeographic.com/environment”}]},{“id”:”natgeo-globalpromo-frame1-history-tile”,”cmsType”:”RegularStandardPrismTile”,”cId”:”natgeo-globalpromo-frame1-history-tile_d043fda4-bff2-438d-8a21-dda0feee64f4″,”description”:”So you want to contribute to a mass tree planting campaign to combat climate change. 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